Annexin A2 in Proliferative Vitreoretinopathy
Technical Report,30 Sep 2014,29 Sep 2018
Weill Medical College of Cornell University New York United States
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Proliferative vitreoretinopathy PVR is one of the major remaining challenges in retinal surgery. PVR occurs inpatients with previous complex retinal surgery and also in patients with penetrating globe injury, of which there are more than 200,000 worldwide per year. PVR is thought to result from proliferation and migration of retinal pigment epithelial RPE cells, leading to formation of an epiretinal membrane, retinal detachment, and loss of vision. At present, there are no reliable means of preventing this complication of ocular trauma and retinal surgery. In this project, we have addressed specific aims to 1 analyze the PVR response in wild type versus annexin A2-deficient mice, 2 define the role of A2 in the function of activated macrophages and RPE cells in PVR, and 3 examine the expression pattern of A2 in human PVR. We conclude that A2 plays a fundamental role in the pathogenesis of PVR in the mouse, that its expression is needed in both macrophages and RPE cells, and that A2 is extensively expressed within cells of epiretinal membranes in human PVR. Our data suggest that A2 may represent a druggable therapeutic target for the prevention of the PVR response.
- Medicine and Medical Research