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LIGHT-ing Up Prostate Cancer for Immunotherapy

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Technical Report,02 Sep 2015,01 Sep 2019

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University of Southern California Los Angeles United States

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Recent discoveries have demonstrated that the expression of LIGHT molecules within the tumor milieu counteracts cancer immune-evasion mechanisms and instigates activation and migration of T-cells into the tumor however, the delivery of LIGHT to the tumor microenvironment has been a challenge. The overall goal of this project is to develop a targeted therapy that will deliver LIGHT to the tumor microenvironment by generating bispecific fusion proteins that are one-part LIGHT and one-part tumor-vasculature targeting moieties VTP. We show in the final report here that nanogram-dose LIGHT-VTP is able to reduce tumor burden and improve survival in mice bearing prostate cancer tumors, and that combination treatment of low-dose LIGHT-VTP with a therapeutic vaccine results in complete tumor clearance. The funding from this project has allowed us to submit two separate articles on the topic and provide preliminary support for a newly awarded grant to continue the study.

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  • Medicine and Medical Research

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