Glutamate Receptor and Kynurenine Pathway Functioning in the Pathobiology of Gulf War Illness
Technical Report,30 Sep 2018,29 Sep 2019
Baylor College of Medicine Houston United States
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This project examines inflammatory pathway biomarkers obtained from cerebrospinal fluid CSF collected from 46 1990-1991 Gulf War veterans with cases and 23 withoutcontrols Gulf War Illness GWI AIM 1, and test involvement of N-methyl-D-aspartate receptor NMDAR functioning in GWI by administering a single dose of ketamine to 19 cases and 19 controls aim 2 while measuring EEG for NMDAR target engagement and assessment of GWI symptoms up to one week after the infusion. In 2019we focused on subject recruitment for aim 1. Using the Gulf War Registry, advertisements and outreach to veterans at the local VA medical center, we recruited16 subjects for the study in 2019. Of those, 13 10 cases completed study procedures,with 7 subjects 4 cases providing a sample of CSF.
- Medicine and Medical Research