Accession Number:

AD1094832

Title:

Commensal Bacteria with High Homology to Nonmutated Tumor Antigens May Prevent Clinically Effective Vaccination in Breast Cancer

Descriptive Note:

Technical Report,15 Mar 2018,14 Mar 2019

Corporate Author:

University of Washington Seattle United States

Personal Author(s):

Report Date:

2019-04-01

Pagination or Media Count:

9.0

Abstract:

We previously found a significant association of numerous sequence homologies to bacterial species found in the gut microbiome with IL-10-inducing Class II epitopes to tumor antigens and hypothesized that those microbialtumor antigen-specific T-cells will prevent an anti-tumor immune response from developing. Aim 1 is 90 percent complete. We have demonstrated here that T-cells specific for Pseudomonas aeruginosa and the50 percent homologous tumor antigen, YB1, can traffic to an TgMMTV-neu tumor implant. The bacterial and tumor antigen cross-reactive T-cells subsequently promoted tumor growth. These results speak to a potential mechanism as to why whole protein vaccines have been unsuccessful in demonstrating anti-tumor activity in Phase III clinical trials.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE