Diagnosis of Late-Stage, Early-Onset, Small-Fiber Polyneuropathy
Technical Report,30 Sep 2015,29 Sep 2019
Veterans Biomedical Research Institute East Orange United States
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The goal of this study is to determine the prevalence of longstanding early-onset small-fiber polyneuropathy SFPN in Veterans with Gulf War Illness and to translate this information clinically by developing and validating tools to diagnose SFPN more quickly and reliably. Study participants will undergo several tests to determine occurrence of SFPN, specifically Autonomic Function Testing and skin biopsy to detect morphology and count of nerve endings. These tests will be compared to a symptom evaluation questionnaire for SFPN, a neurological exam that measures muscle strength and the ability to feel different sensations, genomic markers specific to SFPN, and pupil measurements including diameter and constriction. Our new screening tools will provide a precise measure of SFPN in a less invasive, more rapid approach to diagnosing small-fiber polyneuropathy in Veterans with Gulf War Illness.
- Medicine and Medical Research