Evaluation of Alternative Splicing Regulators as Targets for Selective Therapy of Triple Negative (Basal) Breast Carcinoma
Technical Report,30 Sep 2018,29 Sep 2019
West Virginia University Morgantown United States
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The goal of this proposal was to evaluate the role of splicing regulators upregulated in triple negative breast cancer in the tumorigenesis process and identify potential therapeutic targets. We previously identified three splicing factors, SRPK1, KHDRBS3 and SRSF12, that were expressed at higher levels in triple negative breast cancer compared to other breast cancer subtypes. We proposed to evaluate these splicing factors for their ability to support the tumorigenic properties of basal type breast cancer cells, and the formation of tumors in mouse model of triple negative breast cancer.