Repositioning Antimalarial Drug Quinacrine To Enhance Carboplatin Sensitivity In Ovarian Cancer
Technical Report,15 Aug 2015,14 Aug 2019
MAYO CLINIC ROCHESTER United States
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Based preliminary data and additional data generated by this project, we have determined that the antimalarial drug Quinacrine QC reduces cell viability and promotes chemotherapy induced cell death in an autophagy-dependent manner more extensively in chemoresistant cells compared to their isogenic chemosensitive control cells as quantified by the Chou-Talalay methodology. Overall, our results show for the first time that synergy with QC and carboplatin involves a complex interplay between AV and apoptosis in OVCa cells and is associated with upregulation of INP2, downregulation of p62, and simultaneous upregulation of CTSL only in resistant cells.
- Medicine and Medical Research