Accession Number:



A Pilot Trial of Remotely Supervised Transcranial Direct Current Stimulation (RS-tDCS) to Enhance Motor Learning in Progressive Multiple Sclerosis (MS)

Descriptive Note:

Technical Report,01 Jul 2018,30 Jun 2019

Corporate Author:

New York University School of Medicine New York United States

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The purpose of this randomized, double-blind pilot clinical trial is to test the novel treatment approach of anodal transcranial direct current stimulation tDCS to augment manual dexterity training targeted to rehabilitate fine motor functioning in individuals living with progressive multiple sclerosis MS. Treatment will be delivered to individuals at home using a state-of-the-art remotely-supervised tele-medicine protocol, a major advantage for patients with respect to ease of access, feasibility, and minimal burden of in-clinic study visit participation. Specific Aim 1 is to determine the extent to which tDCS paired with manual dexterity training improves fine motor execution on a grasp and lift task. We expect that the impairment in grasp execution will be significantly reduced with active tDCS versus sham tDCS from pre- to post-treatment. Specific Aim 2 is to assess the adaptation or learning of fingertip forces to object weight when tDCS is paired with manual dexterity training. We predict that active vs. sham tDCS paired with training will optimize the difference in the peak load force rates between the light and heavy objects pre- to post-intervention. Training, material and database creation, and randomizationmatching procedures complete. First participant enrolled and completed. Participant enrollment ongoing. No preliminary data analysis to date.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology
  • Biomedical Instrumentation and Bioengineering
  • Medicine and Medical Research
  • Anatomy and Physiology
  • Biomedical Instrumentation and Bioengineering

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