Glutamate Receptor and Kynurenine Pathway Functioning in the Pathobiology of Gulf War Illness
Technical Report,30 Sep 2017,29 Sep 2018
Baylor College of Medicine Houston United States
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This project examines inflammatory pathway biomarkers obtained from cerebrospinal fluid CSF collected from 46 1990-1991 Gulf War veterans with and 23 without Gulf War Illness, and test effects of N-methyl-D-aspartate receptor NMDAR antagonist ketamine on symptoms of Gulf War Illness in 19 cases and 19 controls. In the last period we focused on subject recruitment. On November 29, 2018, accessed information of local veterans from the 1990-1991 Gulf War registry. Using registry information, we send recruitment letters to 92 veterans as of December 31, 2018. Of the 92, we contacted by phone 42 veterans an additional 5 veterans were referred to the study through other sources. Of the 47 veterans, 12 were phone screened. Two met initial inclusion criteria and agreed to a lumbar puncture for CSF collection. One was a screen fail due to excluding medical conditions, and one is completing screening. Our project is behind schedule of subject recruitment, in part because veterans do not agree to the lumbar puncture. In the coming year we will continue subject recruitment, as well as amend the protocol to access other resources for study-related biomarkers, including i biomarkers collected from blood, and ii accessing CSF biorepositories.
- Medicine and Medical Research