Examination of plasma PON1 paraoxonase activity and genotype in Gulf War veterans
Technical Report,30 Sep 2017,29 Sep 2018
Northern California Institute for Research and Education (NCIRE) San Francisco United States
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The goal of this project is to evaluate the extent to which PON1192Gulf War GW-related exposure interactions contribute to the risk for Gulf War Illness GWI, as defined by the Centers for Disease Control and Prevention CDC and Kansas case definitions in a large sample of GW veterans. Specifically, we will 1 determine the associations between GWI and GW-related exposures with the potential for cholinergic effects e.g., personal pesticide use, exposure to OP nerve agents in subgroups of veterans with different PON1192 genotype. 2 determine the associations between GWI and each GW-related cholinergic exposure in subgroups of veterans with different PON1 activity levels and 3 calculate prevalence odds ratios for GWIexposure associations separately for sugbroups of veterans with different PON1192 genotypes and PON1 activity levels.
- Medicine and Medical Research