Accession Number:

AD1094731

Title:

Examination of plasma PON1 paraoxonase activity and genotype in Gulf War veterans

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

Northern California Institute for Research and Education (NCIRE) San Francisco United States

Personal Author(s):

Report Date:

2018-10-01

Pagination or Media Count:

17.0

Abstract:

The goal of this project is to evaluate the extent to which PON1192Gulf War GW-related exposure interactions contribute to the risk for Gulf War Illness GWI, as defined by the Centers for Disease Control and Prevention CDC and Kansas case definitions in a large sample of GW veterans. Specifically, we will 1 determine the associations between GWI and GW-related exposures with the potential for cholinergic effects e.g., personal pesticide use, exposure to OP nerve agents in subgroups of veterans with different PON1192 genotype. 2 determine the associations between GWI and each GW-related cholinergic exposure in subgroups of veterans with different PON1 activity levels and 3 calculate prevalence odds ratios for GWIexposure associations separately for sugbroups of veterans with different PON1192 genotypes and PON1 activity levels.

Subject Categories:

  • Medicine and Medical Research
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE