Furanyl Fatty Acid Inhibition of FABP5 as a Mechanism for Treatment and Prevention of Cancer
Technical Report,30 Sep 2017,29 Sep 2018
CASE WESTERN RESERVE UNIVERSITY CLEVELAND United States
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We propose that inhibition of FABP5 represents a novel approach to diverting endogenous RA from proproliferative PPAR to anti-proliferative RAR receptors, and further propose the use of furancontaining fatty acids as agents to target RA to RAR. We hypothesize that this pharmacologic inhibition will prevent the oncogenic effects of FABP5 overexpression in highly relevant breast cancer models that display a high ratio of FABP5CRABP2 expression.