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Grandparental Exposures and Risk of Autism in the Third Generation

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Technical Report,15 Jul 2018,14 Jul 2019

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Public Health Institute Oakland United States

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In the second year, we identified.21,772 Child Health and Development Studies grandchildren F2 by linking to the California Birth Records, which was slightly greater than our original estimate of 20,000. Using address. history files, we verified 18,371 CHDS grandchildrenbirths. We were able to support our matching results by using self-reported child bearing births of F2 data collected from a subset of our cohort second generation Fl women. This comparison supported the validity of our matching efforts to identify our CHDS F2. By linkingthe verified births to the California Department of Developmental Services records we have successfully identified 116 autism cases in our cohort which exceeds our initial estimate of 72. we will use a prospective study of 18,371 CHDS grandchildren F2 with 116 autism casesto explore the effect of grandparental FO exposures. This will be the first study of its kind in the United States, linking three generations from the 1960s through the 2010s and will establish a platform for studying germline exposures and risk of autism.

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  • Medicine and Medical Research

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