Restoring Function After Volumetric Muscle Loss: Extracellular Matrix Allograft or Minced Muscle Autograft
Technical Report,30 Sep 2016,16 Jul 2018
The Geneva Foundation Tacoma United States
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We proposed a randomized surgical trial to restore muscle function following a severe muscle injury using muscle autograft intends to restore functional muscle units. The proposed surgical technique in this trial was a new surgical procedure using the patients own autograft muscle tissue from a large, uninjured muscle group. Prior small and large animal studies in our laboratory have demonstrated that minced muscle autograft MMA, by virtue of providing myogenic, angiogenic, neurogenic, and immune modulatory capacity to the injured area, results in regeneration of functional muscle units which integrate with underlying muscle mass. We hypothesized that minced muscle autograft MMA for the treatment of VML will yield greater restoration of muscle volume, greater improvement in validated functional measurements and self-reported outcomes, and greater myogenesis and single fiber strength compared to treatment with ECM. Despite multiple attempts at recruitment, potentially eligible subjects and potential subjects who were interested in undergoing additional surgery were unable to be identified. Once recruitment was determined to not be feasible, the trial was stopped early with no subjects enrolled.
- Anatomy and Physiology