Accession Number:

AD1094648

Title:

Beta Blockers for the Prevention of Acute Exacerbations of COPD

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

University of Alabama at Birmingham Birmingham United States

Personal Author(s):

Report Date:

2018-10-01

Pagination or Media Count:

25.0

Abstract:

We are conducting a multicenter, randomized, placebo-controlled trial to definitively assess the impact of metoprolol succinate on the rate and severity of COPD exacerbations. The trial will enroll 1028 patients with at least moderately severe COPD over a 3-year period. Majoractivities for this reporting period have centered on recruiting and enrollment at clinical sites, launching recruitment advertising campaigns locally, and the addition of new clinical sites to remediate recruitment lag including regulatory approvals, training, and site initiation. The monthly enrollment goal is 28.5 across all sites, with each site enrolling an average of 2-3 participants per month. Some sites have met and exceeded this goal overall while others are underperforming. At the time of this report 441 subjects have been randomized. We have initiated discussions with the DOD, UAB, and clinical sites regarding extending the recruitment period and redistribution of funds to high performing centers in order to reach the overall enrollment goal.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE