Accession Number:

AD1094627

Title:

Tranexamic Acid and Pharmacokinetics in Severe Traumatic Injury

Descriptive Note:

Technical Report,15 Sep 2014,14 Sep 2018

Corporate Author:

Washington University SAINT LOUIS United States

Report Date:

2018-12-01

Pagination or Media Count:

10.0

Abstract:

The major accomplishments have been the completion of patient enrollment and analysis of the data for the primary manuscript. We are currently writing the manuscript and in the process of considering which secondary analyses to work on after the submission of the primary manuscript. Preliminary major findings are the pharmacodynamics results indicate a volume of distribution of 15.6 L70kg and clearance of 113 mlmin70kg.There were no differences in organ failure or mortality between the 3 study groups, but there was an increase inVTE. VTE was increased in the 2 and 4 gram TXA dose groups compared to placebo. This relationship was maintained after adjusting for potential confounders. There were no differences between immune and hemostatic parameters measured between the three study groups.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE