Accession Number:

AD1094616

Title:

Lung Injury; Relates to Real-Time Endoscopic Monitoring of Single Cells Respiratory Health in Lung

Descriptive Note:

Technical Report,01 Sep 2016,31 Aug 2019

Corporate Author:

Childrens Hospital Los Angeles Los Angeles United States

Report Date:

2019-09-01

Pagination or Media Count:

23.0

Abstract:

The available technologies to assess lung function in the upper airways are time consuming and lack of proper sensitivity, therefore the identification of novel medical tool for the analysis of lung cells health with satisfying sensitivity and specificity will have significant impact for health care system. In this proposal we propose a hybrid imaging system Camera and Raster with two modalities seek and focus. Seek modality is a large field, camera-based reflectance hyperspectral, that provides an intermediate accuracy for measuring lung injuries. This modality is coupled with a standard bronchoscope and already greatly enhances its capabilities. It acquires the reflectance spectrum of lung tissues and provides an intermediate accuracy result on tissue health using Hyperspectral Phasor analysis. Areas of interest with a higher likelihood of lung injury will be imaged using the focus modality, that provides high accuracy on a small field of view. The focus modality allows us to identify the different cell types in the lung and precisely detect the metabolic and bimolecular footprint of the cell and tissue.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE