Early Recognition of Chronic Traumatic Encephalopathy Through FDDNP PET Imaging
Technical Report,30 Sep 2013,29 Sep 2018
Icahn School of Medicine at Mount Sinai New York United States
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The PET biomarker, F-FDDNP 2-1-6-2-F-18fluoroethylmethylamino-2-naphthylethylidene malononitrile FDDNP has shown sensitivity for in vivo detection of tau in addition to -sheet-containing brain amyloid neuroaggregates. Tau protein in a characteristic distribution is felt to be the cardinal pathologic feature of Chronic Traumatic Encephalopathy. This project will examine whether FDDNP PET imaging correlates with, andor can predict, decline in cognitive function in those exposed to cumulative head trauma. All operational aspects of this study have been accomplished including local IRB approval, identification of potential subjects from the Professional Fighters Brain Health Study to recruit, logistics of the study visit and PET FDDNP imaging, case report forms, and electronic data entry. Actual enrollment of subjects has been delayed awaiting approval from the Human Research Protection Office.
- Medicine and Medical Research