FYN is a Key Regulator of Metastasis in Prostate Cancer
Technical Report,15 May 2011,14 May 2015
Cedars-Sinai Medical Center Los Angeles United States
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FYN is a member of SRC-family of kinases that has been found to be particularly unregulated in aggressive prostate cancer. Early work in this study identified its role in promoting metastasis, but later work has highlighted the role of FYN in those cancers with neuroendocrineneural differentiation- a phenomenon seen in treatment-induced small cell neuroendocrine cancers tSCNC, a result of strong pressure on the AR-axis. Related to this behavior, we identified a subset of circulating tumor cells CTCs noted by particularly small nuclei i.e. less than 8.5 micrometer that suggest that this type of tSCNC biology and thus clinical behavior visceral metastasis is at hand. Due to its high levels of FYN expression in lymphocytes, FYN expression could not be well characterized on the CTCs. Newer efforts will now focus on detecting molecular pathways downstream of FYN to better characterize this circulating biomarker which may better identify patients who would benefit from FYN inhibition as part of a therapeutic strategy.
- Medicine and Medical Research