Molecular and Cellular Determinants of Malignant Transformation in Lung Squamous Cell Carcinoma
Technical Report,01 Sep 2017,31 Aug 2018
University of California, Los Angeles Los Angeles United States
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During the first funding period we partially completed Major Tasks 1 and 2. The areas of interest were identified in 22 squamous cell lung cancer patient and isolated by LCM. Genomic DNA was isolated from these areas and whole exome sequencing was performed. The data is being analyzed for the progression-associated, premalignant- and malignant-specific mutations. The mutational data is being analyzed in the pathway context. Based on the mutational analysis, neoantigens are being identified as well as analysis of the lesion-infiltrating lymphocytes.
- Medicine and Medical Research