Accession Number:

AD1094473

Title:

Identification of lncRNAs Required for Synthetic Lethal Interactions with Mutant KRAS in Pancreatic Cancer

Descriptive Note:

Technical Report,15 Sep 2018,14 Sep 2019

Corporate Author:

University of Mississippi Medical Center Jackson United States

Personal Author(s):

Report Date:

2019-10-01

Pagination or Media Count:

7.0

Abstract:

The major goal of this application is to identify lncRNAs involved in synthetic lethal interaction with KRAS in pancreatic cancer. There are two specific aims. The first aim is to screen for synthetic lethal interactions between lncRNAs and KRAS using the genome-wide CRISPRCas9-based lncRNA libraries. The second aim is functional characterization of candidate synthetic lethal lncRNAs in pancreatic cancer. The success of this study will help identify novel biomarkers and develop a better strategy for pancreatic cancer treatment.

Subject Categories:

  • Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE