Identification of lncRNAs Required for Synthetic Lethal Interactions with Mutant KRAS in Pancreatic Cancer
Technical Report,15 Sep 2018,14 Sep 2019
University of Mississippi Medical Center Jackson United States
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The major goal of this application is to identify lncRNAs involved in synthetic lethal interaction with KRAS in pancreatic cancer. There are two specific aims. The first aim is to screen for synthetic lethal interactions between lncRNAs and KRAS using the genome-wide CRISPRCas9-based lncRNA libraries. The second aim is functional characterization of candidate synthetic lethal lncRNAs in pancreatic cancer. The success of this study will help identify novel biomarkers and develop a better strategy for pancreatic cancer treatment.
- Medicine and Medical Research