Accession Number:

AD1094466

Title:

Extremity Regeneration of Soft Tissue Injury Using Growth Factor-Impregnated Gels

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

Brigham and Womens Hospital Boston United States

Personal Author(s):

Report Date:

2018-10-01

Pagination or Media Count:

35.0

Abstract:

Due to contamination of coccidioidomycosis within the animal facility, there was a delay of four months. Despite this, seven swine surgeries have been performed during this period, totaling 12 since the start of this study. We have now begun testing the optimal dose of VEGF and IGF in addition to completing the optimal ischemia studies. A total of five swine have been followed to completion at four months post-operatively. We continue to refine our post-operative protocol to minimize insensate traumas which have led to wound necrosis and ultimately euthanasia of four swine. Ongoing studies to evaluate nerve and vessel regeneration continue to be tested. There has been ongoing research and development on the alginate gels and growth factors through collaboration with the Wyss Institute.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE