Tumor Microenvironment-Based Biomarkers in African American Prostate Cancer
Technical Report,01 Sep 2018,31 Aug 2019
BAYLOR COLLEGE OF MEDICINE HOUSTON United States
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African American AA men have a higher incidence and significantly higher mortality rates from prostate cancer PCa than European American EA men. The central problem addressed in this proposal is to understand the biological basis for the more aggressive clinical behavior of PCa in AA men, to develop predictive tools to help manage PCa in AA men and identify novel therapeutic targets in PCa in AA men. We will test the hypothesis that AA PCa has both more extensive reactive stroma formation than in EA PCa and that there are qualitative differences in protein expression in the reactive stroma of AA PCa compared to EA PCa as well. Furthermore, we will determine if these differences in reactive stroma can explain, at least in part, the more aggressive clinical behavior of AA PCa. Our objective is to develop novel predictive tools that will be useful in treatment planning in AA men with PCa.
- Medicine and Medical Research