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Diagnostic and Therapeutic Strategy to Prevent Trauma-Induced Upper-Extremity Muscle Fibrosis and Heterotopic Ossification

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Technical Report,30 Sep 2018,29 Sep 2019

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Regents of the University of Michigan Ann Arbor United States

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Heterotopic ossification HO is a devastating condition in which ectopic bone forms inappropriately in the soft tissue following large surface area burns, musculoskeletal trauma, and many orthopedic surgeries. The military population has been shown to be particularly at risk of HO following battlefield wounds. Clinical detection of HO in patients is currently limited by poor visualization at early time points. At present, HO is often only visualized after it has formed, as diagnosis relies on the use of CT and MRI to identify ectopic lesions. Early diagnosis would allow for pharmacological treatment in order to arrest bone development, instead of surgical excision, often the only treatment strategy currently available, which often leads to additional ectopic bone formation. Here, we aim to further develop a novel high frequency spectral ultrasound imaging system as a method to detect HO formation at early time points and then appropriately deliver timed, guided treatments to prevent bone development. Additionally, we will investigate targeted delivery of FDA approved inhibitors of hypoxic signaling rapamycin and amphotericin B following HO detection using SUSI imaging to direct treatment.

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  • Medicine and Medical Research

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