Reducing tau as a Therapeutic Strategy for Improving Cognitive Dysfunction in Parkinson's Disease
Technical Report,15 Sep 2017,14 Sep 2018
University of Alabama at Birmingham Birmingham United States
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The goal of this proposal is to address the NETPR mission by assessing tau reduction as a therapeutic intervention point for preventing dementia and mood disorders in PD. Neuronal protein inclusions composed of alpha-synuclein alpha-syn called Lewy bodies and Lewy neurites are primary characteristics in brains from PD patients. To test this, we are using a model of PD in which exposure of neurons to alpha-syn fibrils induces formation of inclusions from endogenously expressed alpha-syn that recapitulate many features of inclusions in diseased brains. During this research period we found that there are fewer alpha-syn inclusions in cultured neurons from tau knockout mice compared to control neurons. In the next cycle we will determine if reduction of tau prevents inclusion formation in the cortex, hippocampus and amygdala, in vivo.
- Medicine and Medical Research