Accession Number:

AD1094420

Title:

Endogenous and Exogenous Pericytes in the Pathobiology and Treatment of Osteoarthritis

Descriptive Note:

Technical Report,01 Jul 2018,30 Jun 2019

Corporate Author:

Johns Hopkins University Baltimore United States

Personal Author(s):

Report Date:

2019-07-01

Pagination or Media Count:

20.0

Abstract:

Pdgfrb transgenic reporter animals represent a tool for the visualization of pericytes within joint associated tissues. Destabilization of the medial meniscus in the mouse induces osteoarthritic changes associated with dynamic changes in the vasculature and Pdgfrb reporter activity within the infrapatellar fat pad. These changes implicate endogenous pericytes as a key cellular player in post-traumatic osteoarthritis.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE