Accession Number:

AD1094323

Title:

Furanyl Fatty Acid Inhibition of FABP5 as a Mechanism for Treatment and Prevention of Cancer

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

Case Western Reserve University Cleveland United States

Personal Author(s):

Report Date:

2018-11-01

Pagination or Media Count:

9.0

Abstract:

We propose that inhibition of FABP5 represents a novel approach to diverting endogenous RA from pro-proliferative PPAR delta to anti-proliferative RAR receptors, and further propose the use of furan-containing fatty acids as agents to target RA to RAR. We hypothesize that this pharmacologic inhibition will prevent the oncogenic effects of FABP5 overexpression in highly relevant breast cancer models that display a high ratio of FABP5 CRABP-II expression.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE