Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis
Technical Report,15 Aug 2015,14 Aug 2018
University of Texas health Science Center San Antonio United States
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We defined effects of the immune co-signaling molecule B7-H1 on colitis and cancer development, and effects on immune events in colon. Specific objectives. 1. Define the effects of colon B7-H1 on colitis and development of colon cancer. 2. Test if altering colon B7-H1 signals using recombinant Listeria could affect colitis and subsequent colon cancer. Significant results or key outcomes. We have shown that hostB7-H1 and gut B7-H1 contribute to colitis and colon cancer development. These data provide the proof of concept that targeting this molecule can help reduce colon cancer or treat it. We showed that conventional T cells can induce colon cancer and unconventional T cells can inhibit colon cancer. We showed that B7-H1 alters the gut microbiome to alter colitis and cancer. These data help understand colon cancer immunopathogenesis for future preventiontreatment approaches. We identified specific immune molecules and cells participating in colitis and colon cancer to inform further studies.
- Medicine and Medical Research