VIPER: Chronic Pain after Amputation: Inflammatory Mechanisms, Novel Analgesic Pathways, and Improved Patient Safety
Technical Report,15 Sep 2017,14 Sep 2018
Duke University Durham United States
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Chronic pain is a significant problem after nerve injury from trauma or surgery. Current therapies and attempts at prevention have proven largely ineffective. Through analysis of data obtained in the Molecular Signatures of Chronic Pain Subtypes study termed Veterans Integrated Pain Evaluation ResearchVIPER W81XWH-11-2-0003 we have discovered two novel pain pathways with potential therapeutic relevance Wnt and TGR5. In addition, we recognize that improving the safety and efficacy of existing therapies must continue to be a priority and plan to use the large pharmacogenomic database at Vanderbilt University to identify patients at risk for adverse opioid related events. The current proposal intends to study the contribution of non-neuronal immune cells macrophages to chronic pain while also evaluating novel analgesics in relevant animal models. The current proposal also attempts to determine the optimal patient population for opioid therapy while identifying those patients at greatest risk from opioids.
- Anatomy and Physiology