An Integrated Genomics and Cell Biology Approach to Correlate Novel GWI Indicators of Infections and Neuroinflammatory Mechanisms with Targeted Drug Therapy
Technical Report,01 Jul 2015,31 Dec 2018
Nova Southeastern University Fort Lauderdale United States
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Gulf War Illness GWI is a complex condition that is associated with variety of symptoms including fatigue, headache, memory problems, muscle and joint pain, gastrointestinal issues, neurological problems, hormonal imbalance and immune dysfunction. The condition appears to affect both men and women who were deployed to the GW, with up to one-third of these affected veterans remaining ill today. Currently, little is known about what causes the onset and progression of the disease. Therefore, diagnosis is made based on a process of elimination and treatment involves symptom management, rather than targeting the underlying mechanism of the disease. While little is known about the inner workings of GWI, recent data has suggested that the condition is likely caused by a combination of factors including an individuals genomic make-up and environmental exposures, such as toxic chemicals andor illnesses. Further exacerbation or chronic stress exposure during and after war-time may also contribute to aggravation and persistence of GWI. The goal of our research efforts is to develop a better understanding of genomic characteristics as well as alterations in cellular mechanisms that contribute to the development of the disease.
- Medicine and Medical Research