Cancer Risks Associated with Inherited Mutations in Ovarian Cancer Susceptibility Genes Beyond BRCA1 and BRCA2
Technical Report,15 Apr 2015,14 Oct 2018
University of Washington Seattle United States
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Ovarian, peritoneal and fallopian tube carcinomas OC are the most deadly of the gynecological cancers. Our data indicate that at least 20 percent of unselected OC is hereditary and that 20-25 percent of inherited mutations occur in genes other than BRCA1 and BRCA2. The large fraction of OC associated with inherited mutations in a variety of genes provides an important opportunity to reduce OC mortality. Maximizing the benefit from OC risk assessment and prevention requires an improved understanding of the penetrance of OC genes beyond BRCA12. Furthermore, minimal data exist regarding the hereditary component of OC, including BRCA12, in non-white populations. Our study defined the genetic causes of hereditary OC in African Americans AA as well as the spectrum of cancers, the age of onset, and the relative risk associated with mutations in non-BRCA12 genes.
- Medicine and Medical Research