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Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI

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Technical Report,30 Sep 2014,29 Sep 2018

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University of Alabama at Birmingham Birmingham United States

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This study evaluated Constraint-Induced Movement CI therapy for promoting motor recovery in veterans and civilians with traumatic brain injury TBI. This form of physical rehabilitation has been shown to substantially improve motor function after brain injury not due to trauma and to provoke a widespread neuroplastic response in the brain. This single blind, randomized controlled trial N 40 compared CI therapy for improving use of the more-affected arm in adults with TBI to a holistic fitness program named Lakeshore Enriched Fitness Training LEFT. In addition to assessing changes from pre-treatment in more-affected arm motor function at post-treatment and 1-year afterwards, changes were examined in white matter, grey matter, and functional brain activity. Products at the end of the four years of this blinded study were a manual of procedures, a method for generating synthetic neuroimaging data for the purpose of evaluating the sensitvity of the techniques proposed for quantifying changes in grey matter, and a manuscript on the study protocol.

Subject Categories:

  • Medicine and Medical Research
  • Weapons Effects (Biological)

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