Accession Number:

AD1094135

Title:

Development of a PET Prostate-Specific Membrane Antigen Imaging Agent: Preclinical Translation for Future Clinical Application

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

University of California San Francisco United States

Personal Author(s):

Report Date:

2018-10-01

Pagination or Media Count:

16.0

Abstract:

The overall objective of this research project is to collect chemistry and preclinical data on two promising new small-molecule peptidomimetic imaging agents labeled with positron emitting fluorine-18. These data will enable the filing of an exploratory IND expIND phase 0 application to the FDA by the end of the funding period. The small molecule imaging agents under study home to prostate specific membrane antigen PSMA that is prevalent on a majority of prostate cancers. The availability of these imaging agents will support diagnosis and staging of prostate cancer without the need for a biopsy as well as provide valuable information to guide therapeutic intervention and monitor the treatment outcome.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE