Comprehensive Molecular Profiling of African-American Prostate Cancer to Inform on Prognosis and Disease Biology
Technical Report,30 Sep 2015,29 Sep 2018
Regents of the University of Michigan Ann Arbor United States
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Epidemiological studies consistently show worse prostate cancer PCa incidence and mortality rates in African American AA vs. whiteCaucasian CA men. Although the etiology is likely multi-factorial, AA PCa may arise through distinct pathways and harbor unique molecular alterations. We hypothesized that comprehensive molecular analysis of a carefully annotated AA PCa cohort will inform on the applicability of PCa prognostic signatures and identify novel drivers of aggressive disease in AA patients, thereby impacting the clinical management of AA patients and improving our understanding of the molecular events that underlie racial disparities in PCa behavior. Herein, we generated integrative DNA and RNA profiles of over 200 PCa from AA men. Although we did not identify novel molecular alterations as mediators of aggressive disease, we found altered distribution of known PCa molecular subtypes as well as identified percent genome alteration and TP53 as indepdently predictors of metastasis after surgery.
- Medicine and Medical Research