Accession Number:

AD1093928

Title:

Hemodynamic Changes and Pancreatitis

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

Yale University

Personal Author(s):

• Iwakiri, Yasuko

Report Date:

2019-07-01

Pagination or Media Count:

16

Abstract:

The proposed project relates to the FY17 PRMRP topic area on pancreatitis. The project will explore a previously undescribed mechanism of acute pancreatitis in which pathological hemodynamic changes in the pancreas could induce acute pancreatitis responses. Two Aims are proposed. Aim 1 will determine the mechanism by which pathological hemodynamic changes cause acute pancreatitis. In Aim 2, we will determine the role of lymphangiogenesis in the development andor the resolution of acute pancreatitis. During the reporting period, we have established tissue clearing method necessary for 3-dimentional imaging of lymphatic vessels in the pancreas. The method will be useful for analysis of not only lymphatic vessels, but also other cells in the pancreas. We also showed that macrophages promote pancreatic lymphangiogenesis in mice with portal hypertension.

Descriptors:

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]