Hemodynamic Changes and Pancreatitis
[Technical Report, Annual Report]
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The proposed project relates to the FY17 PRMRP topic area on pancreatitis. The project will explore a previously undescribed mechanism of acute pancreatitis in which pathological hemodynamic changes in the pancreas could induce acute pancreatitis responses. Two Aims are proposed. Aim 1 will determine the mechanism by which pathological hemodynamic changes cause acute pancreatitis. In Aim 2, we will determine the role of lymphangiogenesis in the development andor the resolution of acute pancreatitis. During the reporting period, we have established tissue clearing method necessary for 3-dimentional imaging of lymphatic vessels in the pancreas. The method will be useful for analysis of not only lymphatic vessels, but also other cells in the pancreas. We also showed that macrophages promote pancreatic lymphangiogenesis in mice with portal hypertension.
- Medicine and Medical Research