Pharmacology of Polycystic Kidney Disease Proteins
Technical Report,01 Jun 2017,30 Nov 2018
University of Utah Salt Lake City United States
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The primary goal of this proposal is to identify regulators, in particular activators, of PKD1 and PKD2 proteins for future pharmacological dissection of their structures and functions that will shed light on pathogenesis of ADPKD. Aim 1 Identify small molecule activators of PKD proteins by liposome flux assay. Aim 2 Identify cone snail peptide regulators of PKD proteins. Aim 3 Generate conformation-sensitive, functional antibodies for PKD proteins.
- Medicine and Medical Research