Accession Number:

AD1093920

Title:

Pharmacology of Polycystic Kidney Disease Proteins

Descriptive Note:

Technical Report,01 Jun 2017,30 Nov 2018

Corporate Author:

University of Utah Salt Lake City United States

Personal Author(s):

• Cao,Erhu

Report Date:

2019-03-01

Pagination or Media Count:

9.0

Abstract:

The primary goal of this proposal is to identify regulators, in particular activators, of PKD1 and PKD2 proteins for future pharmacological dissection of their structures and functions that will shed light on pathogenesis of ADPKD. Aim 1 Identify small molecule activators of PKD proteins by liposome flux assay. Aim 2 Identify cone snail peptide regulators of PKD proteins. Aim 3 Generate conformation-sensitive, functional antibodies for PKD proteins.

Descriptors:

• Pharmacology
• kidney diseases
• antibodies
• synthetic membranes
• amino acids peptides and proteins
• biopolymers
• pathogenesis

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE