Understanding the Role of Matrix Microstructure in Metastasis
[Technical Report, Annual Report]
University of Rochester
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In this project we will address the underlying mechanisms by which certain light-scattering properties of the tumor ECM predict metastasis. Understanding the mechanisms of this novel phenomenon may yield novel insights into metastatic processes, leading to new treatments for metastatic breast cancer. It may also uncover additional prognostic indicators, improving our predictive ability and further reducing overtreatment. The light scattering phenomenon in question is the direction that second harmonic generation light scatters from collagen fibers, the FB ratio. FB is sensitive to the diameter of fibrils that are bundled into collagen fibers, as well as the spacing and disorder of their packing within the fiber, altogether known as a fibers microstructure. To begin to address why collagen microstructure, reported by FB, predicts patients metastatic outcome, we must first determine how that microstructure is defined by cells within the tumor, and the cues that influence those cells to do so.
- Medicine and Medical Research