Accession Number:

AD1093903

Title:

Understanding the Role of Matrix Microstructure in Metastasis

Descriptive Note:

Technical Report,01 Feb 2018,31 Jan 2019

Corporate Author:

University of Rochester Rochester United States

Personal Author(s):

• Brown,Edward
• Kuo,Catherine

Report Date:

2019-02-01

Pagination or Media Count:

23.0

Abstract:

In this project we will address the underlying mechanisms by which certain light-scattering properties of the tumor ECM predict metastasis. Understanding the mechanisms of this novel phenomenon may yield novel insights into metastatic processes, leading to new treatments for metastatic breast cancer. It may also uncover additional prognostic indicators, improving our predictive ability and further reducing overtreatment. The light scattering phenomenon in question is the direction that second harmonic generation light scatters from collagen fibers, the FB ratio. FB is sensitive to the diameter of fibrils that are bundled into collagen fibers, as well as the spacing and disorder of their packing within the fiber, altogether known as a fibers microstructure. To begin to address why collagen microstructure, reported by FB, predicts patients metastatic outcome, we must firs determine how that microstructure is defined by cells within the tumor, and the cues that influence those cells to do so.

Descriptors:

• microscopy
• metastasis
• neoplasms
• breast cancer
• collagen
• electromagnetic scattering
• chemotherapy
• surgery

Subject Categories:

• Medicine and Medical Research
• Atomic and Molecular Physics and Spectroscopy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE