Accession Number:

AD1093893

Title:

Side-to-Side Supercharging Allograft

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

Virginia Commonwealth University

Personal Author(s):

• Isaacs, Jonathan

Report Date:

2019-07-01

Pagination or Media Count:

29

Abstract:

Side-to-side bridge grafting into chronically denervated nerve tissue has been shown to enhance the neurotrophic environment and increase axon regeneration and may be useful in processed acellular nerve allograft PNA. Rodent tibial nerves were repaired with 20mm or 40mm isograft or PNA with 0, 1 or 3 side-to-side bridge grafts. Testing at 20 weeks consisted of muscle and nerve assessment including neuron back-labeling. Average recovered force production with 40mm PNA3 bridge grafts was greater than with untreated 40mm PNA. Schwann cell counts were higher at the bridge points in the PNA. A greater proportion of senescent cells were detected in the distal aspect of the untreated 40mm PNA compared to all other 40mm grafts. Retrograde labeling demonstrated only between 6.6 and 17.7 of the reinnervating neurons were derived from the peroneal nerve pool. Side-to-side grafting seemed to improve the neurotrophic environment in long PNA.

Descriptors:

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology

Distribution Statement:

[A, Approved For Public Release]