Encoding of Multiple Reward-Related Computations in Transient and Sustained High-Frequency Activity in Human OFC
Journal Article - Open Access
University of California, Berkeley Berkely United States
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Human orbitofrontal cortex OFC has long been implicated in value-based decisionmaking. In recent years, convergent evidence from human and model organisms has further elucidated its role in representing reward-related computations underlying decision making. However, a detailed description of these processes remains elusive due in part to 1 limitations in our ability to observe human OFC neural dynamics at the timescale of decision processes and 2 methodological and interspecies differences that make it challenging to connect human and animal findings orto resolve discrepancies when they arise. Here, we sought to address these challenges by conducting multi-electrode electrocorticography ECoG recordings in neurosurgical patients during economic decision making to elucidate the electrophysiological signature, sub-second temporal profile, and anatomical distribution of reward-related computations within human OFC.