Optimizing Skin-Implant Interface of Osseointegrated Device
Technical Report,15 Sep 2017,14 Sep 2018
Henry M Jackson Foundation for the Advancement of Military Medicine Bethesda United States
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This study focuses on an OI prosthetic implant anchored in the long bone of a residual limb and exiting through the skin. Implant and soft-tissue infections and implant loosening are common complications for both upper and lower extremity bone-anchored implants, resulting in revision surgeries and increased morbidity. We explore the possibility of creating a tight, durable skin-implant interface for OI implants using mesenchymal stem cells MSCs derived from naturally occurring porcine integumentary tissues or human induced pluripotent stem iPS cells, which have the intrinsic potential to form an impervious seal at hard and soft tissue junctions. Initial porcine cell characterization is ongoing.
- Anatomy and Physiology
- Medicine and Medical Research