Comprehensive Study of Acute Effects and Recovery After Concussion
Technical Report,30 Sep 2017,29 Sep 2018
Medical College of Wisconsin MILWAUKEE United States
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Utilizing a multi-dimensional research model, this study integrates biomechanical, clinical, neurobiological, and neuroradiological markers of mTBI, with the ultimate goal to more fully inform a neurobiopsychosocial model of mTBI risk, recovery and outcome. With the goal of baseline testing 900 athletes and enrolling 50 injured athletes and 50 contact and 50 non-contact controls over the course of 3 years, the project has surpassed all targets ahead of schedule and on budget. During the first 3 years of the study, we have enrolled 1174 at baseline and accrued 107 concussed athletes in the multidimensional postinjury protocol, along with 137 non-injured control athletes. All groups are undergoing follow up evaluations within 6 hours of injury, 48 hours after injury, and 8, 15, and 45 days after injury. These evaluations include advanced brain neuroimaging, blood biospecimen collection, and clinical testing measures assessing balance, neurocognition, symptoms, and psychological health, which will be correlated with data from the Head Impact Telemetry System HITS.Several lines of preliminary analysis have been presented at national research meetings, submitted for publication, and published in peer-reviewed journals. Further data analyses are underway, with our investigative team developing advanced database platforms and analysis techniques. Major progress has been achieved with regard to an advanced platform and pipeline for MRI data processing, quality control and integration. Ongoing collaboration with co-investigators and our project partners has guided us to a successful execution of this comprehensive study, which will lead to advancing the science of mTBI and improving clinical care in military, sports, and civilian populations. This projects focus on high school and lower level collegiate athletes makes it fully distinct from the NCAA-DoD CARE Consortium.
- Medicine and Medical Research