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MicroRNA in Prostate Cancer Racial Disparities and Aggressiveness

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[Technical Report, Final Report]

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Wayne State University

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We examined the association of plasma miRNA levels and inherited polymorphisms in genes in the microRNA miRNA biogenesis pathway with prostate cancer aggressiveness among African American AA and European American EA men with prostate cancer PCa from the Karmanos Cancer Institute in Detroit, MI. We demonstrated that a previously unreported circulating miRNA signature consisting of two distinct combinations of miRNAs miR-17miR-192 and miR-146amiR-20amiR26b is capable of segregating aggressive and non-aggressive prostate cancer in both AA and EA patients. When we evaluated SNPs in genes involved in the miRNA biogenesis pathway, multiple SNPs in TARBP1, DROSHA and DICER1 were significantly associated with PCa aggressiveness in AA men. Fewer SNPs were significantly associated with PCa aggressiveness in EA men, and were primarily located in TARBP1 and DROSHA. Only 1 SNP was significant for both the AA and EA adjusted analyses rs4920247, which is an intronic SNP located in TARBP1.


Subject Categories:

  • Medicine and Medical Research

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[A, Approved For Public Release]