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Validation of Structural, Molecular, and Functional Imaging Biomarkers in Spinal Cord Injury in Non-Human Primates

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Technical Report,15 Jul 2018,14 Jul 2019

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Vanderbilt University Medical Center Nashville United States

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Spinal cord injuries SCI impair sensory, autonomic andor motor functions, and area leading cause of disability. The process of spontaneous repair of damaged SC is poorly understood because of a lack of appropriate longitudinal tracking methods. Such a method would provide the information needed for a basic understanding of recovery processes and for determining the optimal time window, targets and effectiveness of therapeutic interventions. Combinations of novel, advanced MRI methods can provide unique insights into SCI progression, especially into the functional integrity of grey matter and micro-structural and biochemical changes in white matter. Much previous work in rodent models has limited significance for human injuries, but studies in non-human primates are directly applicable. We propose to use non-invasive multiparametric MRI at high field to assess changes in structural, functional and cellularmolecular properties of SCI over time in a monkey model and determine how these changes predict and correlate with behavioral recovery.

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  • Medicine and Medical Research

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