Accession Number:

AD1093440

Title:

Statins Prevent Pancreatic Diseases through Mitophagy Activation

Descriptive Note:

Technical Report,01 May 2017,30 Apr 2019

Corporate Author:

Cedars-Sinai Medical Center Los Angeles United States

Personal Author(s):

• Pandol,Stephen

Report Date:

2019-08-01

Pagination or Media Count:

28.0

Abstract:

This proposal addressing FY16 PRMRP topic area Pancreatitis is designed to determine the mechanisms of statin mediated protection from pancreatitis, an observation recently reported using a retrospective cohort analysis of large clinical datasets. Prevention of pancreatitis, especially cases that progress to recurrent acute and chronic pancreatitis is of high relevance because there is no treatment for these disorders and because the progression is associated with an extremely high risk of pancreatic cancer, one of the most lethal human cancers.

Descriptors:

• Statins
• Pancreatitis
• mitochondria
• proteins
• deoxyribonucleic acids
• inhibition
• metabolism

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE