Accession Number:

AD1093352

Title:

Discovery and Characterization of PRCAT47: A Novel Prostate Lineage and Cancer-Specific Long Noncoding RNA

Descriptive Note:

Technical Report,01 Jul 2016,30 Jun 2019

Corporate Author:

University of Michigan Ann Arbor United States

Personal Author(s):

Report Date:

2019-10-01

Pagination or Media Count:

42.0

Abstract:

The overall goal of this project is to characterize the functioning mechanism, utility and therapeutic potential of the biomarker PRCAT47 in prostate cancer. During this second period, we investigated the regulatory effect of PRCAT47 on androgen receptor ARtranscript stability. We also interrogated the role of PRCAT47 in regulating HuRTIAR-targeted mRNAs. Utilizing a novel RNA in situ hybridization technology optimized within the first period which allows us to assess PRCAT47 expression in prostate tissues, we have not evaluatedPRCAT47 expression in prostate cancer tissue microarrays by RNA-ISH and demonstrate an association with prostate cancer progression. Finally, we also assessed the therapeutic potential of PRCAT47 using cell line models and patient derived organoid cultures.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE