Accession Number:

AD1093189

Title:

DAMP-Mediated Innate Immune Failure and Pneumonia After Trauma

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

Beth Israel Deaconess Medical Center Boston United States

Personal Author(s):

• Hauser,Carl J.
• Otterbein,Leo E.
• Robson,Simon
• Talmor,Daniel
• Lederer,Jamie
• Yaffe,Michael

Report Date:

2018-10-01

Pagination or Media Count:

51.0

Abstract:

Lung infection is extremely common after injury. Injuries like combat wounds are linked to infections distal from the injury site due in part to release of specific molecules called Damage Associated Molecular Patterns DAMPs. Cellular injury renders the host immunologically susceptible to infection. After major injury, DAMP release alters immune responses creating a systemic environment that is permissive of infection. This program collectively studies the production of multiple DAMPs in clinical trauma patient populations that have been aligned with highly specific laboratory models. This approach allows mechanistic studies by which production of DAMPs, released as a result of tissue injury, predisposes the host to pneumonia. Importantly, we are developing novel therapeutic treatment strategies and deliverables that will reduce the incidence of acute lung injury and promote recovery from trauma.

Descriptors:

• Mitochondria
• trauma
• lung
• infection
• wounds and injuries
• Pneumonia
• therapy

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE