Accession Number:

AD1093142

Title:

Electric Field Stimulation Enhances Healing of Post-Traumatic Osteoarthritic Cartilage

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2018

Corporate Author:

Columbia University New York United States

Personal Author(s):

• Bulinski,Jeannette C.

Report Date:

2018-12-01

Pagination or Media Count:

36.0

Abstract:

Trauma can cause osteoarthritis OA, and since no effective strategies exist to prevent the inflammation and apoptosis that develop, joint injuries from sports or combat almost always develop into OA. Basic studies can help to establish and therapeutically target the progression of traumatic injury into OA, using animal models, in our case the dog. We proposed to use electric fields to direct cartilage precursor cells to OA damage sites, and optimize differentiation there. We also developed matrix components to introduce into the injury site, to further enhance healing, proposing that our strategy could promote healing of cartilage in dogs, and be translatable to humans.

Descriptors:

• ARTHRITIS
• joint diseases
• collagen
• trauma
• inflammation
• combat injuries
• therapy
• wounds and injuries
• dogs
• animal experimentation
• electric fields

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE