Development of Tethered Hsp90 Inhibitors Carrying Radioiodinated Probes to Specifically Discriminate and Kill Malignant Breast Tumor Cells
Technical Report,01 May 2017,30 Apr 2018
Duke University Durham United States
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Our work this year focused on continued development of our chemistry platform with the synthesis of a novel photo-acoustic tethered Hsp90 inhibitor. Our goal is to enable this probe for PET imaging by introducing an iodine. This probe combination will have better utility for interfacing our technology with current standard of practice mammography programs. Pharmacokinetic studies with 124IHS-227, a Cy5 carrying radioiodinated tethered Hsp90 inhibitor, showed very rapid clearance following injection into tumor bearing mice. Our studies suggest that large bolus doses or infusion are required to enable effective tumor detection by PETCT.
- Medicine and Medical Research