Accession Number:

AD1093137

Title:

Development of Tethered Hsp90 Inhibitors Carrying Radioiodinated Probes to Specifically Discriminate and Kill Malignant Breast Tumor Cells

Descriptive Note:

Technical Report,01 May 2017,30 Apr 2018

Corporate Author:

Duke University Durham United States

Personal Author(s):

• Haystead,Timothy

Report Date:

2018-05-01

Pagination or Media Count:

10.0

Abstract:

Our work this year focused on continued development of our chemistry platform with the synthesis of a novel photo-acoustic tethered Hsp90 inhibitor. Our goal is to enable this probe for PET imaging by introducing an iodine. This probe combination will have better utility for interfacing our technology with current standard of practice mammography programs. Pharmacokinetic studies with 124IHS-227, a Cy5 carrying radioiodinated tethered Hsp90 inhibitor, showed very rapid clearance following injection into tumor bearing mice. Our studies suggest that large bolus doses or infusion are required to enable effective tumor detection by PETCT.

Descriptors:

• breast cancer
• cancer research
• inhibitors
• therapy
• neoplasms
• detection
• tumor cell line
• gene expression
• metastasis
• diagnosis (medicine)
• POSITRON EMISSION TOMOGRAPHY

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE