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Accession Number:
AD1093107
Title:
Randomized Controlled Trial of Sertraline, Prolonged Exposure Therapy and their Combination in OEF/OIF Combat Veterans with PTSD
Descriptive Note:
Technical Report,01 Dec 2011,31 Dec 2018
Corporate Author:
Veterans Education and Research Association of Michigan (VERAM) Ann Arbor United States
Report Date:
2019-03-01
Pagination or Media Count:
95.0
Abstract:
The study directly compared the psychotherapy and medication treatments for PTSD considered to have the most evidence for effectiveness. While both SSRI and PE have demonstrated efficacy, there are significant individual differences in clinical responses to both treatments. To achieve best clinical outcomes and to utilize available treatment most effectively, it is critical to examine how PTSD and related psychopathology and functional impairment change with these treatments alone and in combination. Further, in order to inform clinical practice, we examined psychological and neurobiological predictors of response to treatment and mechanisms of change during treatment pre to post treatment change based on previously identified predictors, including emotion regulation and processing with fMRI in response to emotional challenge tasks, DNA and mRNA pre and post treatment, and cortisol response to awakening. The final enrollment numbers were 223 Veterans randomized to treatment which 120 completed both of their assigned treatments, 149 completed the Week 24 primary outcome assessment visit and 139 have completed the Week 52 final study assessment visit. The primary activity and focus this year was data analyses and manuscript preparation with 6 papers published to date and the main results of the study published in JAMA Psychiatry in February 2019.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
