Accession Number:

AD1092702

Title:

Targeting Diet-Microbiome Interactions in the Pathogenesis of Parkinson's Disease

Descriptive Note:

Technical Report,01 Sep 2018,31 Aug 2019

Corporate Author:

California Institute of Technology Pasadena United States

Personal Author(s):

Report Date:

2019-09-01

Pagination or Media Count:

11.0

Abstract:

The current project will analyze the gut microbiome and metabolites from PD patients and controls, and employ clinically relevant mouse models to determine how metabolites produced by the microbiome from dietary substrates affect motor symptoms. We propose to test whether directly regulating microbial metabolite profiles using designer dietary fibers and probiotics offers new avenues for ameliorating PD-like symptoms.

Subject Categories:

  • Biology
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE